Preclinical Characterization and In Vivo Efficacy of GSK8853, a Small-Molecule Inhibitor of the Hepatitis C Virus NS4B Protein

The hepatitis C virus (HCV) NS4B protein is an antiviral therapeutic target for which small-molecule inhibitors have not been shown to exhibit in vivo efficacy. We describe here the in vitro and in vivo antiviral activity of GSK8853, an imidazo[1,2-a]pyrimidine inhibitor that binds NS4B protein. GSK...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Pouliot, Jeffrey J., Thomson, Michael, Xie, Mi, Horton, Joseph, Johnson, John, Krull, David, Mathis, Amanda, Morikawa, Yoshio, Parks, Derek, Peterson, Richard, Shimada, Takashi, Thomas, Elizabeth, Vamathevan, Jessica, Van Horn, Stephanie, Xiong, Zhiping, Hamatake, Robert, Peat, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2015
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576073/
https://ncbi.nlm.nih.gov/pubmed/26259798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00813-15
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