In Vitro Characterization of GSK2485852, a Novel Hepatitis C Virus Polymerase Inhibitor

GSK2485852 (referred to here as GSK5852) is a hepatitis C virus (HCV) NS5B polymerase inhibitor with 50% effective concentrations (EC(50)s) in the low nanomolar range in the genotype 1 and 2 subgenomic replicon system as well as the infectious HCV cell culture system. We have characterized the antiv...

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Detalhes bibliográficos
Main Authors: Voitenleitner, Christian, Crosby, Renae, Walker, Jill, Remlinger, Katja, Vamathevan, Jessica, Wang, Amy, You, Shihyun, Johnson, John, Woldu, Ermias, Van Horn, Stephanie, Horton, Joseph, Creech, Katrina, Shotwell, J. Brad, Hong, Zhi, Hamatake, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811320/
https://ncbi.nlm.nih.gov/pubmed/23939896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00874-13
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