Imidazo[1,2-a]pyridines That Directly Interact with Hepatitis C NS4B: Initial Preclinical Characterization

[Image: see text] A series of imidazo[1,2-a]pyridines which directly bind to HCV Non-Structural Protein 4B (NS4B) is described. This series demonstrates potent in vitro inhibition of HCV replication (EC(50) < 10 nM), direct binding to purified NS4B protein (IC(50) < 20 nM), and an HCV resistan...

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Detalhes bibliográficos
Main Authors: Shotwell, J. Brad, Baskaran, Subramanian, Chong, Pek, Creech, Katrina L., Crosby, Renae M., Dickson, Hamilton, Fang, Jing, Garrido, Dulce, Mathis, Amanda, Maung, Jack, Parks, Derek J., Pouliot, Jeffrey J., Price, Daniel J., Rai, Roopa, Seal, John W., Schmitz, Uli, Tai, Vincent W. F., Thomson, Michael, Xie, Mi, Xiong, Zhiping Z., Peat, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025644/
https://ncbi.nlm.nih.gov/pubmed/24900511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300090x
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