Imidazo[1,2-a]pyridines That Directly Interact with Hepatitis C NS4B: Initial Preclinical Characterization

[Image: see text] A series of imidazo[1,2-a]pyridines which directly bind to HCV Non-Structural Protein 4B (NS4B) is described. This series demonstrates potent in vitro inhibition of HCV replication (EC(50) < 10 nM), direct binding to purified NS4B protein (IC(50) < 20 nM), and an HCV resistan...

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Bibliografiske detaljer
Main Authors: Shotwell, J. Brad, Baskaran, Subramanian, Chong, Pek, Creech, Katrina L., Crosby, Renae M., Dickson, Hamilton, Fang, Jing, Garrido, Dulce, Mathis, Amanda, Maung, Jack, Parks, Derek J., Pouliot, Jeffrey J., Price, Daniel J., Rai, Roopa, Seal, John W., Schmitz, Uli, Tai, Vincent W. F., Thomson, Michael, Xie, Mi, Xiong, Zhiping Z., Peat, Andrew J.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2012
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025644/
https://ncbi.nlm.nih.gov/pubmed/24900511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300090x
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