Differential Effects of Penicillin Binding Protein Deletion on the Susceptibility of Enterococcus faecium to Cationic Peptide Antibiotics

Beta-lactam antibiotics sensitize Enterococcus faecium to killing by endogenous antimicrobial peptides (AMPs) of the innate immune system and daptomycin through mechanisms yet to be elucidated. It has been speculated that beta-lactam inactivation of select E. faecium penicillin binding proteins (PBP...

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Библиографические подробности
Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Sakoulas, George, Kumaraswamy, Monika, Nonejuie, Poochit, Werth, Brian J., Rybak, Micahel J., Pogliano, Joseph, Rice, Louis B., Nizet, Victor
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2015
Предметы:
Mechanisms of Action: Physiological Effects
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576044/
https://ncbi.nlm.nih.gov/pubmed/26195528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00486-15
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