Penicillin Binding Protein 1 Is Important in the Compensatory Response of Staphylococcus aureus to Daptomycin-Induced Membrane Damage and Is a Potential Target for β-Lactam–Daptomycin Synergy

The activity of daptomycin (DAP) against methicillin-resistant Staphylococcus aureus (MRSA) is enhanced in the presence of β-lactam antibiotics. This effect is more pronounced with β-lactam antibiotics that exhibit avid binding to penicillin binding protein 1 (PBP1). Here, we present evidence that P...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Berti, Andrew D., Theisen, Erin, Sauer, John-Demian, Nonejuie, Poochit, Olson, Joshua, Pogliano, Joseph, Sakoulas, George, Nizet, Victor, Proctor, Richard A., Rose, Warren E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
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Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704217/
https://ncbi.nlm.nih.gov/pubmed/26525797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02071-15
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