Differential Effects of Penicillin Binding Protein Deletion on the Susceptibility of Enterococcus faecium to Cationic Peptide Antibiotics

Beta-lactam antibiotics sensitize Enterococcus faecium to killing by endogenous antimicrobial peptides (AMPs) of the innate immune system and daptomycin through mechanisms yet to be elucidated. It has been speculated that beta-lactam inactivation of select E. faecium penicillin binding proteins (PBP...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Sakoulas, George, Kumaraswamy, Monika, Nonejuie, Poochit, Werth, Brian J., Rybak, Micahel J., Pogliano, Joseph, Rice, Louis B., Nizet, Victor
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576044/
https://ncbi.nlm.nih.gov/pubmed/26195528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00486-15
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