Intrinsic differences in donor CD4 T cell IL-2 production influence severity of parent-into-F1 murine lupus by skewing the immune response either towards help for B cells and a sustained autoantibody response or towards help for CD8 T cells and a down regulatory Th1 response

Using the parent-into-F1 model of induced lupus and (C57Bl/6xDBA2) F1 mice as hosts, we compared the inherent lupus-inducing properties of the two parental strain CD4 T cells. To control for donor CD4 recognition of alloantigen, we used H-2(d) identical DBA/2 and B10.D2 donor T cells. We demonstrate...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Soloviova, Kateryna, Puliaiev, Maksym, Haas, Mark, Dalgard, Clifton L., Schaefer, Brian C., Via, Charles S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575913/
https://ncbi.nlm.nih.gov/pubmed/26320249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402782
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