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Intrinsic differences in donor CD4 T cell IL-2 production influence severity of parent-into-F1 murine lupus by skewing the immune response either towards help for B cells and a sustained autoantibody response or towards help for CD8 T cells and a down regulatory Th1 response
Using the parent-into-F1 model of induced lupus and (C57Bl/6xDBA2) F1 mice as hosts, we compared the inherent lupus-inducing properties of the two parental strain CD4 T cells. To control for donor CD4 recognition of alloantigen, we used H-2(d) identical DBA/2 and B10.D2 donor T cells. We demonstrate...
Sparad:
| I publikationen: | J Immunol |
|---|---|
| Huvudupphovsmän: | , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2015
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4575913/ https://ncbi.nlm.nih.gov/pubmed/26320249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402782 |
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