The presence and preferential activation of Tregs diminishes adoptive transfer of autoimmune diabetes by polyclonal NOD T cell effectors into NSG versus NOD-scid mice()

NOD-scid.Il2rg(null) (NSG) mice are currently being used as recipients to screen for pathogenic autoreactive T-cells in Type 1 Diabetes (T1D) patients. We questioned whether the restriction of IL-2 receptor gamma chain (Il-2rγ) dependent cytokine signaling only to donor cells in NSG recipients diffe...

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Bibliographic Details
Published in:J Immunol
Main Authors: Presa, Maximiliano, Chen, Yi-Guang, Grier, Alexandra E., Leiter, Edward H., Brehm, Michael A., Greiner, Dale L., Shultz, Leonard D., Serreze, David V.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575869/
https://ncbi.nlm.nih.gov/pubmed/26283479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402446
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