MCPIP1 endoribonuclease activity negatively regulates interleukin-17-mediated signaling and inflammation

Interleukin-17 (IL-17) induces pathology in autoimmunity and infections; therefore constraint of this pathway is an essential component of its regulation. We demonstrate that the signaling intermediate MCPIP1 (also termed Regnase-1, encoded by Zc3h12a) is a feedback inhibitor of IL-17 receptor signa...

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Bibliografske podrobnosti
izdano v:Immunity
Main Authors: Garg, Abhishek V., Amatya, Nilesh, Chen, Kong, Cruz, J. Agustin, Grover, Prerna, Whibley, Natasha, Conti, Heather R., Mir, Gerard Hernandez, Sirakova, Tatiana, Childs, Erin C., Smithgall, Thomas E., Biswas, Partha S., Kolls, Jay K., McGeachy, Mandy J., Kolattukudy, Pappachan E., Gaffen, Sarah L.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575280/
https://ncbi.nlm.nih.gov/pubmed/26320658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.07.021
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