MCPIP1 endoribonuclease activity negatively regulates interleukin-17-mediated signaling and inflammation

Interleukin-17 (IL-17) induces pathology in autoimmunity and infections; therefore constraint of this pathway is an essential component of its regulation. We demonstrate that the signaling intermediate MCPIP1 (also termed Regnase-1, encoded by Zc3h12a) is a feedback inhibitor of IL-17 receptor signa...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Garg, Abhishek V., Amatya, Nilesh, Chen, Kong, Cruz, J. Agustin, Grover, Prerna, Whibley, Natasha, Conti, Heather R., Mir, Gerard Hernandez, Sirakova, Tatiana, Childs, Erin C., Smithgall, Thomas E., Biswas, Partha S., Kolls, Jay K., McGeachy, Mandy J., Kolattukudy, Pappachan E., Gaffen, Sarah L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575280/
https://ncbi.nlm.nih.gov/pubmed/26320658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.07.021
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