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High-Throughput Ligand Discovery Reveals a Sitewise Gradient of Diversity in Broadly Evolved Hydrophilic Fibronectin Domains

Discovering new binding function via a combinatorial library in small protein scaffolds requires balance between appropriate mutations to introduce favorable intermolecular interactions while maintaining intramolecular integrity. Sitewise constraints exist in a non-spatial gradient from diverse to c...

詳細記述

保存先:
書誌詳細
出版年:PLoS One
主要な著者: Woldring, Daniel R., Holec, Patrick V., Zhou, Hong, Hackel, Benjamin J.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575168/
https://ncbi.nlm.nih.gov/pubmed/26383268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138956
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