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Designed hydrophilic and charge mutations of the fibronectin domain: towards tailored protein biodistribution
Engineered proteins are attractive affinity scaffolds for molecular imaging and drug delivery. Although exquisite binding specificity and affinity can be engineered, many proteins exhibit off-target uptake, particularly in the kidneys and liver, from physiologic effects. We quantified the ability to...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2012
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3449399/ https://ncbi.nlm.nih.gov/pubmed/22691700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzs036 |
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