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Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

To delineate specific developmental roles of transforming growth factor beta 1 (TGF-beta 1) we have disrupted its cognate gene in mouse embryonic stem cells by homologous recombination to generate TGF-beta 1 null mice. These mice do not produce detectable amounts of either TGF-beta 1 RNA or protein....

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Kulkarni, A B, Huh, C G, Becker, D, Geiser, A, Lyght, M, Flanders, K C, Roberts, A B, Sporn, M B, Ward, J M, Karlsson, S
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45747/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8421714/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.2.770
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