The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.

All three isoforms of transforming growth factors beta (TGF-betal, TGF-beta2, and TGF-beta3) are secreted as latent complexes and activated extracellularly, leading to the release of the mature cytokines from their noncovalently associated proregions, also known as latency-associated peptides (LAPs)...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Böttinger, E P, Factor, V M, Tsang, M L, Weatherbee, J A, Kopp, J B, Qian, S W, Wakefield, L M, Roberts, A B, Thorgeirsson, S S, Sporn, M B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39155/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8650186/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.12.5877
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