The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.

All three isoforms of transforming growth factors beta (TGF-betal, TGF-beta2, and TGF-beta3) are secreted as latent complexes and activated extracellularly, leading to the release of the mature cytokines from their noncovalently associated proregions, also known as latency-associated peptides (LAPs)...

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Autors principals: Böttinger, E P, Factor, V M, Tsang, M L, Weatherbee, J A, Kopp, J B, Qian, S W, Wakefield, L M, Roberts, A B, Thorgeirsson, S S, Sporn, M B
Format: Artigo
Idioma:Inglês
Publicat: 1996
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC39155/
https://ncbi.nlm.nih.gov/pubmed/8650186
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