High expression of human beta S- and alpha-globins in transgenic mice: erythrocyte abnormalities, organ damage, and the effect of hypoxia.

A line of transgenic mice with two cointegrated transgenes, the human beta S- and alpha 2-globin genes, linked to the beta-globin locus control region was produced and bred with mice carrying a deletion of the mouse beta major-globin gene. In transgenic mice homozygous for the beta major deletion (a...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Fabry, M E, Costantini, F, Pachnis, A, Suzuka, S M, Bank, N, Aynedjian, H S, Factor, S M, Nagel, R L
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1992
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50717/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1465455/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.24.12155
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