EFFICACY OF RETINOIDS IN IKZF1-MUTATED BCR-ABL1 ACUTE LYMPHOBLASTIC LEUKEMIA

Alterations of IKZF1, encoding the lymphoid transcription factor IKAROS, are a hallmark of high risk acute lymphoblastic leukemia (ALL), however the role of IKZF1 alterations in ALL pathogenesis is poorly understood. Here we show that in mouse models of BCR-ABL1 leukemia, Ikzf1 and Arf alterations s...

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Publié dans:Cancer Cell
Auteurs principaux: Churchman, Michelle L., Low, Jonathan, Qu, Chunxu, Paietta, Elisabeth M., Kasper, Lawryn H., Chang, Yunchao, Payne-Turner, Debbie, Althoff, Mark J., Song, Guangchun, Chen, Shann-Ching, Ma, Jing, Rusch, Michael, McGoldrick, Dan, Edmonson, Michael, Gupta, Pankaj, Wang, Yong-Dong, Caufield, William, Freeman, Burgess, Li, Lie, Panetta, John C., Baker, Sharyn, Yang, Yung-Li, Roberts, Kathryn G., McCastlain, Kelly, Iacobucci, Ilaria, Peters, Jennifer L., Centonze, Victoria E., Notta, Faiyaz, Dobson, Stephanie M., Zandi, Sasan, Dick, John E., Janke, Laura, Peng, Junmin, Kodali, Kiran, Pagala, Vishwajeeth, Min, Jaeki, Mayasundari, Anand, Williams, Richard T., Willman, Cheryl L., Rowe, Jacob, Luger, Selina, Dickins, Ross A., Guy, R. Kiplin, Chen, Taosheng, Mullighan, Charles G.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573904/
https://ncbi.nlm.nih.gov/pubmed/26321221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.07.016
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