Exposure–response model for sibutramine and placebo: suggestion for application to long-term weight-control drug development

No wholly successful weight-control drugs have been developed to date, despite the tremendous demand. We present an exposure–response model of sibutramine mesylate that can be applied during clinical development of other weight-control drugs. Additionally, we provide a model-based evaluation of sibu...

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Bibliographic Details
Published in:Drug Des Devel Ther
Main Authors: Han, Seunghoon, Jeon, Sangil, Hong, Taegon, Lee, Jongtae, Bae, Soo Hyeon, Park, Wan-su, Park, Gab-jin, Youn, Sunil, Jang, Doo Yeon, Kim, Kyung-Soo, Yim, Dong-Seok
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2015
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573071/
https://ncbi.nlm.nih.gov/pubmed/26392753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S85435
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