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Design Parameters for Granzyme-Mediated Cytotoxic Lymphocyte Target-Cell Killing and Specificity

Cytotoxic lymphocytes are key elements of the immune system that are primarily responsible for targeting cells infected with intracellular pathogens, or cells that have become malignantly transformed. Target cells are killed mainly via lymphocyte exocytosis of specialized lysosomes containing perfor...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Woodsworth, Daniel J., Dunsing, Valentin, Coombs, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572491/
https://ncbi.nlm.nih.gov/pubmed/26244730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.06.045
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