Deficient acid handling with distal RTA in the NBCe2 knockout mouse

In many circumstances, the pathogenesis of distal renal tubular acidosis (dRTA) is not understood. In the present study, we report that a mouse model lacking the electrogenic Na(+)-HCO(3)(−) cotransporter [NBCe2/Slc4a5; NBCe2 knockout (KO) mice] developed dRTA after an oral acid challenge. NBCe2 exp...

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Bibliographic Details
Published in:Am J Physiol Renal Physiol
Main Authors: Wen, Donghai, Yuan, Yang, Cornelius, Ryan J., Li, Huaqing, Warner, Paige C., Wang, Bangchen, Wang-France, Jun, Boettger, Thomas, Sansom, Steven C.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572397/
https://ncbi.nlm.nih.gov/pubmed/26109087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00163.2015
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