Increased ENaC activity contributes to hypertension caused by NBCe2 deficiency

The gene SLC4A5 encodes the Na(+)-HCO(3)(−) co-transporter electrogenic 2 (NBCe2), which is located in the distal nephron. Genetically deleting NBCe2 (KO) causes Na(+)-retention and hypertension, a phenotype that is diminished with alkali loading. We performed experiments with acid-loaded mice and d...

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Publicado en:Hypertension
Autores principales: Wen, Donghai, Yuan, Yang, Warner, Paige C., Wang, Bangchen, Cornelius, Ryan J., Wang-France, Jun, Li, Huaqing, Boettger, Thomas, Sansom, Steven C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465853/
https://ncbi.nlm.nih.gov/pubmed/25941340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.115.05394
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