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Increased ENaC activity contributes to hypertension caused by NBCe2 deficiency
The gene SLC4A5 encodes the Na(+)-HCO(3)(−) co-transporter electrogenic 2 (NBCe2), which is located in the distal nephron. Genetically deleting NBCe2 (KO) causes Na(+)-retention and hypertension, a phenotype that is diminished with alkali loading. We performed experiments with acid-loaded mice and d...
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| Izdano u: | Hypertension |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4465853/ https://ncbi.nlm.nih.gov/pubmed/25941340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.115.05394 |
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