Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions

Interpretation of biological mechanisms underlying genetic risk associations for prostate cancer is complicated by the relatively large number of risk variants (n = 100) and the thousands of surrogate SNPs in linkage disequilibrium. Here, we combined three distinct approaches: multiethnic fine-mappi...

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Publicado en:Hum Mol Genet
Autores principales: Han, Ying, Hazelett, Dennis J., Wiklund, Fredrik, Schumacher, Fredrick R., Stram, Daniel O., Berndt, Sonja I., Wang, Zhaoming, Rand, Kristin A., Hoover, Robert N., Machiela, Mitchell J., Yeager, Merideth, Burdette, Laurie, Chung, Charles C., Hutchinson, Amy, Yu, Kai, Xu, Jianfeng, Travis, Ruth C., Key, Timothy J., Siddiq, Afshan, Canzian, Federico, Takahashi, Atsushi, Kubo, Michiaki, Stanford, Janet L., Kolb, Suzanne, Gapstur, Susan M., Diver, W. Ryan, Stevens, Victoria L., Strom, Sara S., Pettaway, Curtis A., Al Olama, Ali Amin, Kote-Jarai, Zsofia, Eeles, Rosalind A., Yeboah, Edward D., Tettey, Yao, Biritwum, Richard B., Adjei, Andrew A., Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Chokkalingam, Anand P., Isaacs, William B., Chen, Constance, Lindstrom, Sara, Le Marchand, Loic, Giovannucci, Edward L., Pomerantz, Mark, Long, Henry, Li, Fugen, Ma, Jing, Stampfer, Meir, John, Esther M., Ingles, Sue A., Kittles, Rick A., Murphy, Adam B., Blot, William J., Signorello, Lisa B., Zheng, Wei, Albanes, Demetrius, Virtamo, Jarmo, Weinstein, Stephanie, Nemesure, Barbara, Carpten, John, Leske, M. Cristina, Wu, Suh-Yuh, Hennis, Anselm J. M., Rybicki, Benjamin A., Neslund-Dudas, Christine, Hsing, Ann W., Chu, Lisa, Goodman, Phyllis J., Klein, Eric A., Zheng, S. Lilly, Witte, John S., Casey, Graham, Riboli, Elio, Li, Qiyuan, Freedman, Matthew L., Hunter, David J., Gronberg, Henrik, Cook, Michael B., Nakagawa, Hidewaki, Kraft, Peter, Chanock, Stephen J., Easton, Douglas F., Henderson, Brian E., Coetzee, Gerhard A., Conti, David V., Haiman, Christopher A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2015
Materias:
Association Studies Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572069/
https://ncbi.nlm.nih.gov/pubmed/26162851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv269
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