Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions

Interpretation of biological mechanisms underlying genetic risk associations for prostate cancer is complicated by the relatively large number of risk variants (n = 100) and the thousands of surrogate SNPs in linkage disequilibrium. Here, we combined three distinct approaches: multiethnic fine-mappi...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Han, Ying, Hazelett, Dennis J., Wiklund, Fredrik, Schumacher, Fredrick R., Stram, Daniel O., Berndt, Sonja I., Wang, Zhaoming, Rand, Kristin A., Hoover, Robert N., Machiela, Mitchell J., Yeager, Merideth, Burdette, Laurie, Chung, Charles C., Hutchinson, Amy, Yu, Kai, Xu, Jianfeng, Travis, Ruth C., Key, Timothy J., Siddiq, Afshan, Canzian, Federico, Takahashi, Atsushi, Kubo, Michiaki, Stanford, Janet L., Kolb, Suzanne, Gapstur, Susan M., Diver, W. Ryan, Stevens, Victoria L., Strom, Sara S., Pettaway, Curtis A., Al Olama, Ali Amin, Kote-Jarai, Zsofia, Eeles, Rosalind A., Yeboah, Edward D., Tettey, Yao, Biritwum, Richard B., Adjei, Andrew A., Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Chokkalingam, Anand P., Isaacs, William B., Chen, Constance, Lindstrom, Sara, Le Marchand, Loic, Giovannucci, Edward L., Pomerantz, Mark, Long, Henry, Li, Fugen, Ma, Jing, Stampfer, Meir, John, Esther M., Ingles, Sue A., Kittles, Rick A., Murphy, Adam B., Blot, William J., Signorello, Lisa B., Zheng, Wei, Albanes, Demetrius, Virtamo, Jarmo, Weinstein, Stephanie, Nemesure, Barbara, Carpten, John, Leske, M. Cristina, Wu, Suh-Yuh, Hennis, Anselm J. M., Rybicki, Benjamin A., Neslund-Dudas, Christine, Hsing, Ann W., Chu, Lisa, Goodman, Phyllis J., Klein, Eric A., Zheng, S. Lilly, Witte, John S., Casey, Graham, Riboli, Elio, Li, Qiyuan, Freedman, Matthew L., Hunter, David J., Gronberg, Henrik, Cook, Michael B., Nakagawa, Hidewaki, Kraft, Peter, Chanock, Stephen J., Easton, Douglas F., Henderson, Brian E., Coetzee, Gerhard A., Conti, David V., Haiman, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Association Studies Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572069/
https://ncbi.nlm.nih.gov/pubmed/26162851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv269
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