The Role of Protein-Ligand Contacts in Allosteric Regulation of the Escherichia coli Catabolite Activator Protein

Allostery is a fundamental process by which ligand binding to a protein alters its activity at a distant site. Both experimental and theoretical evidence demonstrate that allostery can be communicated through altered slow relaxation protein dynamics without conformational change. The catabolite acti...

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Vydáno v:J Biol Chem
Hlavní autoři: Townsend, Philip D., Rodgers, Thomas L., Glover, Laura C., Korhonen, Heidi J., Richards, Shane A., Colwell, Lucy J., Pohl, Ehmke, Wilson, Mark R., Hodgson, David R. W., McLeish, Tom C. B., Cann, Martin J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Computational Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571973/
https://ncbi.nlm.nih.gov/pubmed/26187469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.669267
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