The Role of Protein-Ligand Contacts in Allosteric Regulation of the Escherichia coli Catabolite Activator Protein

Allostery is a fundamental process by which ligand binding to a protein alters its activity at a distant site. Both experimental and theoretical evidence demonstrate that allostery can be communicated through altered slow relaxation protein dynamics without conformational change. The catabolite acti...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Townsend, Philip D., Rodgers, Thomas L., Glover, Laura C., Korhonen, Heidi J., Richards, Shane A., Colwell, Lucy J., Pohl, Ehmke, Wilson, Mark R., Hodgson, David R. W., McLeish, Tom C. B., Cann, Martin J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Computational Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571973/
https://ncbi.nlm.nih.gov/pubmed/26187469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.669267
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