Modulation of Global Low-Frequency Motions Underlies Allosteric Regulation: Demonstration in CRP/FNR Family Transcription Factors

Allostery is a fundamental process by which ligand binding to a protein alters its activity at a distinct site. There is growing evidence that allosteric cooperativity can be communicated by modulation of protein dynamics without conformational change. The mechanisms, however, for communicating dyna...

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Hlavní autoři: Rodgers, Thomas L., Townsend, Philip D., Burnell, David, Jones, Matthew L., Richards, Shane A., McLeish, Tom C. B., Pohl, Ehmke, Wilson, Mark R., Cann, Martin J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769225/
https://ncbi.nlm.nih.gov/pubmed/24058293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001651
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