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Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin

Following its activation by PINK1, parkin is recruited to depolarized mitochondria where it ubiquitinates outer mitochondrial membrane proteins, initiating lysosomal-mediated degradation of these organelles. Mutations in the gene encoding parkin, PARK2, result in both familial and sporadic forms of...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Siddiqui, Almas, Bhaumik, Dipa, Chinta, Shankar J., Rane, Anand, Rajagopalan, Subramanian, Lieu, Christopher A., Lithgow, Gordon J., Andersen, Julie K.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2015
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571606/
https://ncbi.nlm.nih.gov/pubmed/26377470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0109-15.2015
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