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Regulation of ATP13A2 via PHD2-HIF1α Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease

We previously reported that pharmacological inhibition of a class of enzymes known as prolyl hydroxylase domain proteins (PHDs) has neuroprotective effects in various in vitro and in vivo models of Parkinson's disease (PD). We hypothesized that this was due to inhibition of the PHD2 isoform, pr...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Rajagopalan, Subramanian, Rane, Anand, Chinta, Shankar J., Andersen, Julie K.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404282/
https://ncbi.nlm.nih.gov/pubmed/26818499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3117-15.2016
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