Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

Exposure to the herbicide paraquat (PQ) is associated with an increased risk of idiopathic Parkinson’s disease (PD). Therapies based on PQ’s presumed mechanisms of action have not, however, yielded effective disease therapies. Cellular senescence is an anticancer mechanism that arrests proliferation...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Chinta, Shankar J., Woods, Georgia, Demaria, Marco, Rane, Anand, Zou, Ying, McQuade, Amanda, Rajagopalan, Subramanian, Limbad, Chandani, Madden, David T., Campisi, Judith, Andersen, Julie K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5806534/
https://ncbi.nlm.nih.gov/pubmed/29386135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.12.092
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