Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin

Following its activation by PINK1, parkin is recruited to depolarized mitochondria where it ubiquitinates outer mitochondrial membrane proteins, initiating lysosomal-mediated degradation of these organelles. Mutations in the gene encoding parkin, PARK2, result in both familial and sporadic forms of...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Siddiqui, Almas, Bhaumik, Dipa, Chinta, Shankar J., Rane, Anand, Rajagopalan, Subramanian, Lieu, Christopher A., Lithgow, Gordon J., Andersen, Julie K.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571606/
https://ncbi.nlm.nih.gov/pubmed/26377470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0109-15.2015
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados