Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody

The MERS-CoV is an emerging virus, which already infected more than 1,300 humans with high (∼36%) mortality. Here, we show that m336, an exceptionally potent human anti-MERS-CoV antibody, is almost germline with only one somatic mutation in the heavy chain. The structure of Fab m336 in complex with...

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發表在:Nat Commun
Main Authors: Ying, Tianlei, Prabakaran, Ponraj, Du, Lanying, Shi, Wei, Feng, Yang, Wang, Yanping, Wang, Lingshu, Li, Wei, Jiang, Shibo, Dimitrov, Dimiter S., Zhou, Tongqing
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571279/
https://ncbi.nlm.nih.gov/pubmed/26370782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9223
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