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Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody
The MERS-CoV is an emerging virus, which already infected more than 1,300 humans with high (∼36%) mortality. Here, we show that m336, an exceptionally potent human anti-MERS-CoV antibody, is almost germline with only one somatic mutation in the heavy chain. The structure of Fab m336 in complex with...
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| Publicat a: | Nat Commun |
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| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4571279/ https://ncbi.nlm.nih.gov/pubmed/26370782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9223 |
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