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Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors

PERK is serine/threonine kinase localized to the endoplasmic reticulum (ER) membrane. PERK is activated and contributes to cell survival in response to a variety of physiological stresses that affect protein quality control in the ER, such as hypoxia, glucose depravation, increased lipid biosynthesi...

詳細記述

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書誌詳細
出版年:J Biomol Screen
主要な著者: Pytel, Dariusz, Seyb, Kathleen, Liu, Min, Ray, Soumya S., Concannon, John, Huang, Mickey, Cuny, Gregory D., Diehl, J. Alan, Glicksman, Marcie A.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570879/
https://ncbi.nlm.nih.gov/pubmed/24598103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057114525853
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