Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors

PERK is serine/threonine kinase localized to the endoplasmic reticulum (ER) membrane. PERK is activated and contributes to cell survival in response to a variety of physiological stresses that affect protein quality control in the ER, such as hypoxia, glucose depravation, increased lipid biosynthesi...

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Vydáno v:J Biomol Screen
Hlavní autoři: Pytel, Dariusz, Seyb, Kathleen, Liu, Min, Ray, Soumya S., Concannon, John, Huang, Mickey, Cuny, Gregory D., Diehl, J. Alan, Glicksman, Marcie A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570879/
https://ncbi.nlm.nih.gov/pubmed/24598103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057114525853
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