Fibroblast Growth Factor 21 Limits Lipotoxicity by Promoting Hepatic Fatty Acid Activation in Mice on Methionine and Choline-deficient Diets

BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) is a common consequence of human and rodent obesity. Disruptions in lipid metabolism lead to accumulation of triglycerides and fatty acids, which can promote inflammation and fibrosis and lead to nonalcoholic steatohepatitis (NASH). Cir...

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Опубликовано в: :Gastroenterology
Главные авторы: Fisher, ffolliott M., Chui, Patricia C., Nasser, Imad A., Popov, Yury, Cunniff, Jeremy C., Lundasen, Thomas, Kharitonenkov, Alexei, Schuppan, Detlef, Flier, Jeffrey S., Maratos-Flier, Eleftheria
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570569/
https://ncbi.nlm.nih.gov/pubmed/25083607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.07.044
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