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Engineering trypsin for inhibitor resistance

The development of effective protease therapeutics requires that the proteases be more resistant to naturally occurring inhibitors while maintaining catalytic activity. A key step in developing inhibitor resistance is the identification of key residues in protease-inhibitor interaction. Given that m...

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Vydáno v:Protein Sci
Hlavní autoři: Batt, Anna R, St Germain, Commodore P, Gokey, Trevor, Guliaev, Anton B, Baird, Teaster
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Ltd 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570540/
https://ncbi.nlm.nih.gov/pubmed/26106067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2732
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