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Crystal structure of an engineered subtilisin inhibitor complexed with bovine trypsin.
Proteinase specificity of a proteinaceous inhibitor of subtilisin (SSI; Streptomyces subtilisin inhibitor) can be altered so as to strongly inhibit trypsin simply by replacing P1 methionine with lysine (with or without concomitant change of the P4 residue) through site-directed mutagenesis. Now the...
Wedi'i Gadw mewn:
Prif Awduron: | , , , , , |
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Fformat: | Artigo |
Iaith: | Inglês |
Cyhoeddwyd: |
1992
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Pynciau: | |
Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC49091/ https://ncbi.nlm.nih.gov/pubmed/1584773 |
Tagiau: |
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