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Crystal structure of an engineered subtilisin inhibitor complexed with bovine trypsin.

Proteinase specificity of a proteinaceous inhibitor of subtilisin (SSI; Streptomyces subtilisin inhibitor) can be altered so as to strongly inhibit trypsin simply by replacing P1 methionine with lysine (with or without concomitant change of the P4 residue) through site-directed mutagenesis. Now the...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Takeuchi, Y, Nonaka, T, Nakamura, K T, Kojima, S, Miura, K, Mitsui, Y
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 1992
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC49091/
https://ncbi.nlm.nih.gov/pubmed/1584773
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