Crystal structure of an engineered subtilisin inhibitor complexed with bovine trypsin.
Proteinase specificity of a proteinaceous inhibitor of subtilisin (SSI; Streptomyces subtilisin inhibitor) can be altered so as to strongly inhibit trypsin simply by replacing P1 methionine with lysine (with or without concomitant change of the P4 residue) through site-directed mutagenesis. Now the...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
1992
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49091/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1584773/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.10.4407 |
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