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Increased sensitivity to glucose starvation correlates with downregulation of glycogen phosphorylase isoform PYGB in tumor cell lines resistant to 2-deoxy-d-glucose

BACKGROUND: As tumors evolve, they upregulate glucose metabolism while also encountering intermittent periods of glucose deprivation. Here, we investigate mechanisms by which pancreatic cancer cells respond to therapeutic (2-deoxy-d-glucose, 2-DG) and physiologic (glucose starvation, GS) forms of gl...

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Bibliografske podrobnosti
izdano v:Cancer Chemother Pharmacol
Main Authors: Philips, Katherine B., Kurtoglu, Metin, Leung, Howard J., Liu, Huaping, Gao, Ningguo, Lehrman, Mark A., Murray, Timothy G., Lampidis, Theodore J.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570497/
https://ncbi.nlm.nih.gov/pubmed/24292700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-013-2358-8
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