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Breast cancers utilize hypoxic glycogen stores via PYGB, the brain isoform of glycogen phosphorylase, to promote metastatic phenotypes

In breast cancer, tumor hypoxia has been linked to poor prognosis and increased metastasis. Hypoxia activates transcriptional programs in cancer cells that lead to increased motility and invasion, as well as various metabolic changes. One of these metabolic changes, an increase in glycogen metabolis...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:PLoS One
Κύριοι συγγραφείς: Altemus, Megan A., Goo, Laura E., Little, Andrew C., Yates, Joel A., Cheriyan, Hannah G., Wu, Zhi Fen, Merajver, Sofia D.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2019
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6752868/
https://ncbi.nlm.nih.gov/pubmed/31536495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0220973
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