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Perforin-dependent cytotoxicity: ‘Kiss of death’ or prolonged embrace with darker elocation-idnseque11es?
Failure of natural killer (NK) cells or cytotoxic T-lymphocytes (CTL) to kill cognate target cells results in cytokine/chemokine hypersecretion and markedly delayed killer/target cell detachment. With congenital perforin deficiency, fatal cytokine storm results. In cancer cells, where corrupted apop...
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| 發表在: | Oncoimmunology |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Taylor & Francis
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4570094/ https://ncbi.nlm.nih.gov/pubmed/26405605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1036215 |
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