Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma

Alterations in Hedgehog (Hh) signaling lead to birth defects and cancers including medulloblastoma, the most common pediatric brain tumor. Although inhibitors targeting the membrane protein Smoothened suppress Hh signaling, acquired drug resistance and tumor relapse call for additional therapeutic t...

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Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Ge, Xuecai, Milenkovic, Ljiljana, Suyama, Kaye, Hartl, Tom, Purzner, Teresa, Winans, Amy, Meyer, Tobias, Scott, Matthew P
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2015
Konular:
Developmental Biology and Stem Cells
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569902/
https://ncbi.nlm.nih.gov/pubmed/26371509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07068
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