Neuropilins are positive regulators of Hedgehog signal transduction

The Hedgehog (Hh) pathway is essential for vertebrate embryogenesis, and excessive Hh target gene activation can cause cancer in humans. Here we show that Neuropilin 1 (Nrp1) and Nrp2, transmembrane proteins with roles in axon guidance and vascular endothelial growth factor (VEGF) signaling, are imp...

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Hlavní autoři: Hillman, R. Tyler, Feng, Brian Y., Ni, Jun, Woo, Wei-Meng, Milenkovic, Ljiljana, Hayden Gephart, Melanie G., Teruel, Mary N., Oro, Anthony E., Chen, James K., Scott, Matthew P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2011
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222900/
https://ncbi.nlm.nih.gov/pubmed/22051878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.173054.111
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