Neuropilins are positive regulators of Hedgehog signal transduction

The Hedgehog (Hh) pathway is essential for vertebrate embryogenesis, and excessive Hh target gene activation can cause cancer in humans. Here we show that Neuropilin 1 (Nrp1) and Nrp2, transmembrane proteins with roles in axon guidance and vascular endothelial growth factor (VEGF) signaling, are imp...

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Detalhes bibliográficos
Main Authors: Hillman, R. Tyler, Feng, Brian Y., Ni, Jun, Woo, Wei-Meng, Milenkovic, Ljiljana, Hayden Gephart, Melanie G., Teruel, Mary N., Oro, Anthony E., Chen, James K., Scott, Matthew P.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2011
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222900/
https://ncbi.nlm.nih.gov/pubmed/22051878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.173054.111
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