Neuropilins are positive regulators of Hedgehog signal transduction

The Hedgehog (Hh) pathway is essential for vertebrate embryogenesis, and excessive Hh target gene activation can cause cancer in humans. Here we show that Neuropilin 1 (Nrp1) and Nrp2, transmembrane proteins with roles in axon guidance and vascular endothelial growth factor (VEGF) signaling, are imp...

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Main Authors: Hillman, R. Tyler, Feng, Brian Y., Ni, Jun, Woo, Wei-Meng, Milenkovic, Ljiljana, Hayden Gephart, Melanie G., Teruel, Mary N., Oro, Anthony E., Chen, James K., Scott, Matthew P.
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2011
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Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222900/
https://ncbi.nlm.nih.gov/pubmed/22051878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.173054.111
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