Novel Fluorinated 8-Hydroxyquinoline Based Metal Ionophores for Exploring the Metal Hypothesis of Alzheimer’s Disease

[Image: see text] Zinc, copper, and iron ions are involved in amyloid-beta (Aβ) deposition and stabilization in Alzheimer’s disease (AD). Consequently, metal binding agents that prevent metal-Aβ interaction and lead to the dissolution of Aβ deposits have become well sought therapeutic and diagnostic...

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Publicado en:ACS Med Chem Lett
Main Authors: Liang, Steven H., Southon, Adam G., Fraser, Benjamin H., Krause-Heuer, Anwen M., Zhang, Bo, Shoup, Timothy M., Lewis, Rebecca, Volitakis, Irene, Han, Yifeng, Greguric, Ivan, Bush, Ashley I., Vasdev, Neil
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2015
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569883/
https://ncbi.nlm.nih.gov/pubmed/26396692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00281
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