Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease

We have previously demonstrated that brief treatment of APP transgenic mice with metal ionophores (PBT2, Prana Biotechnology) rapidly and markedly improves learning and memory. To understand the potential mechanisms of action underlying this phenomenon we examined hippocampal dendritic spine density...

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Hlavní autoři: Adlard, Paul A., Bica, Laura, White, Anthony R., Nurjono, Milawaty, Filiz, Gulay, Crouch, Peter J., Donnelly, Paul S., Cappai, Roberto, Finkelstein, David I., Bush, Ashley I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055881/
https://ncbi.nlm.nih.gov/pubmed/21412423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017669
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