Fragment-Based Drug Design of Novel Pyranopyridones as Cell Active and Orally Bioavailable Tankyrase Inhibitors

[Image: see text] Tankyrase activity has been linked to the regulation of intracellular axin levels, which have been shown to be crucial for the Wnt pathway. Deregulated Wnt signaling is important for the genesis of many diseases including cancer. We describe herein the discovery and development of...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: de Vicente, Javier, Tivitmahaisoon, Parcharee, Berry, Pamela, Bolin, David R., Carvajal, Daisy, He, Wei, Huang, Kuo-Sen, Janson, Cheryl, Liang, Lena, Lukacs, Christine, Petersen, Ann, Qian, Hong, Yi, Lin, Zhuang, Yong, Hermann, Johannes C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569882/
https://ncbi.nlm.nih.gov/pubmed/26396691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00251
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