Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor

[Image: see text] A focused high throughput screening for GPR139 was completed for a select 100K compounds, and new agonist leads were identified. Subsequent analysis and structure–activity relationship studies identified (S)-3-chloro-N-(2-oxo-2-((1-phenylethyl)amino)ethyl)benzamide 7c as a potent a...

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Publicado en:ACS Med Chem Lett
Main Authors: Dvorak, Curt A., Coate, Heather, Nepomuceno, Diane, Wennerholm, Michelle, Kuei, Chester, Lord, Brian, Woody, David, Bonaventure, Pascal, Liu, Changlu, Lovenberg, Timothy, Carruthers, Nicholas I.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2015
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569879/
https://ncbi.nlm.nih.gov/pubmed/26396690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00247
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