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Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects

[Image: see text] Following the characterization of the lactate receptor (GPR81), a focused screening effort afforded 3-hydroxybenzoic acid 1 as a weak agonist of both GPR81 and GPR109a (niacin receptor). An examination of structurally similar arylhydroxy acids led to the identification of 3-chloro-...

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Hlavní autoři: Dvorak, Curt A., Liu, Changlu, Shelton, Jonathan, Kuei, Chester, Sutton, Steven W., Lovenberg, Timothy W., Carruthers, Nicholas I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2012
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025785/
https://ncbi.nlm.nih.gov/pubmed/24900524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3000676
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