Design, Synthesis, and Biological Evaluation of Indole Biphenylcarboxylic Acids as PPARγ Antagonists

[Image: see text] The thiazolidinediones (TZD) typified by rosiglitazone are the only approved therapeutics targeting PPARγ for the treatment of type-2 diabetes (T2DM). Unfortunately, despite robust insulin sensitizing properties, they are accompanied by a number of severe side effects including con...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Asteian, Alice, Blayo, Anne-Laure, He, Yuanjun, Koenig, Marcel, Shin, Youseung, Kuruvilla, Dana S., Corzo, Cesar A., Cameron, Michael D., Lin, Li, Ruiz, Claudia, Khan, Susan, Kumar, Naresh, Busby, Scott, Marciano, David P., Garcia-Ordonez, Ruben D., Griffin, Patrick R., Kamenecka, Theodore M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2015
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569877/
https://ncbi.nlm.nih.gov/pubmed/26396687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00218
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